Integrating In Vitro Analytics for Improved Antibody-Drug Conjugate Candidate Selection.

ABSTRACT:

Background/objectives

The development of antibody-drug conjugates (ADCs) presents significant scientific and operational challenges, from optimising conjugation chemistry and linker stability to establishing robust analytical controls. Advanced analytical methods, particularly the combination of plasma stability assays with enzymatic studies, are essential for early screening and characterisation of ADC candidates. Integrating these in vitro assays with powerful data analysis software accelerates structure-activity relationship assessments and the identification of stable compounds in plasma.

Methods

This article examines how combined analytical and computational approaches enhance candidate selection by offering valuable insights into the metabolic fate and stability risks

SUBMITTER: Del Solar V 

PROVIDER: S-EPMC12784668 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature