Functional miRNA Transfer in Models of Serous Ovarian Carcinoma.

ABSTRACT:

Background

Intracellular miRNA transfer is an intriguing and lesser-described mode of intracellular communication. Epithelial ovarian carcinoma, of which the high-grade serous histotype represents the most common and deadliest form, is characterized by a microenvironment consisting of tumor and stromal cells, ascitic fluid, and extracellular matrix, presenting a rich milieu of factors that can affect neighboring cells.

Methods

We examined the mode of miR transfer in serous ovarian carcinoma cell lines cultured on different extracellular matrix supports both in two-dimensional and three-dimensional formats coupled with traditional, live-cell time-lapse, multiphoton fluorescence imaging modalities, and fluorescence-activated cell sorting approaches.

Results

Our data dem

SUBMITTER: Muralidhar GG 

PROVIDER: S-EPMC12784692 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature