Association Between Dietary Inflammatory and Oxidative Balance Scores and Skin Cancer Risk: The Mediating Role of Accelerated Phenotypic Aging.

ABSTRACT:

Background

Skin cancer is known to be associated with aging, oxidative stress, and inflammation. The present study aimed to explore the association between PhenoAge, dietary inflammatory index (DII), and dietary oxidative balance index (DOBS) with skin cancer risk.

Methods

A total of 474 individuals aged over 20 years who had information on DII, DOBS, PhenoAge, socioeconomic and demographic factors, and self-reported skin cancer, and 16,154 without skin cancer were included in the National Health and Nutrition Examination Survey database (2005-2018). The combination of DII/DOBS was categorized into 3 categories: inflammation- and oxidation-promoting diet, inflammation- and oxidation-reducing diet, and composite diet. We applied logistic regression to estimate odds ratios (OR

SUBMITTER: Hui S 

PROVIDER: S-EPMC12784734 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature