Toxic Epidermal Necrolysis and Mortality: A Danish Cohort Study With 30 Years of Follow-Up.

ABSTRACT: Toxic epidermal necrolysis (TEN) is a rare, life-threatening dermatologic condition, typically triggered by medications. While increased short-term mortality in this group is well documented, few studies have quantified this risk over extended follow-up. We aimed to examine both short- and long-term mortality and assess whether excess mortality persists beyond the acute phase. We conducted a nationwide, register-based matched cohort study using Danish health registries. Patients with a first-time hospital diagnosis of TEN between 1995 and 2024 were included and matched 1:100 on age and sex with population controls. Short-term mortality (30- and 90-day) was calculated, and long-term mortality was assessed overall and in a landmark analysis restricted to 2-year survivors with newly matched c

SUBMITTER: Heerfordt IM 

PROVIDER: S-EPMC12784798 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature