Resolving Clinically Indeterminate Findings During Anal Cancer Surveillance with TTMV-HPV DNA.

ABSTRACT:

Background/objectives

Surveillance for anal squamous cell carcinoma (ASCC) recurrence relies on clinical examination and imaging. Post-treatment edema, fibrosis, and inflammation can result in clinically indeterminate findings (CIFs) that delay diagnosis and increase patient and system burden. Circulating tumor tissue-modified viral (TTMV)-HPV DNA offers a biologically specific, noninvasive biomarker that may clarify equivocal assessments.

Methods

In this multi-center retrospective study, 233 patients with HPV-associated ASCC were evaluated, including 185 with ≥1 post-treatment TTMV-HPV DNA test. CIFs were defined as exams or imaging results not definitively positive or negative for disease, and were paired with subsequent TTMV-HPV DNA tests. Concordance was defined by presp

SUBMITTER: Kabarriti R 

PROVIDER: S-EPMC12784822 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature