Long COVID Patients with Orthostatic Intolerance Have Reduced Heart Rate Variability and Preserved Physiological Response to Active Standing.

ABSTRACT: The aim of this study was to assess the heart rate variability (HRV) at rest and during active orthostatic challenge in long COVID patients with orthostatic intolerance symptoms (dizziness, pre-syncope, and syncope). We performed a cross-sectional, observational, comparative study of 60 subjects of both sexes, aged 18 to 60 years (31 met the criteria of long COVID, 15 were infected individuals without symptoms, and 14 who had neither infection nor symptoms formed the age-matched control group). HRV was obtained from continuous electrocardiograms in a supine position and active standing with spontaneous breathing. The time from SARS-CoV-2 infection to testing in the COVID-19 group was 573 ± 289 days. The resting (supine position) values of SDNN, RMSSD, SD1, and SD2 were lower in long COVID

SUBMITTER: Gonzalez-Hermosillo Gonzalez JA 

PROVIDER: S-EPMC12784901 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature