Segment-Specific Functional Responses of Swine Intestine to Time-Restricted Feeding Regime.

ABSTRACT: Research indicates that TRF improves mammalian metabolism and health via the microbiota-gut-brain axis. Previous studies showed that TRF promotes pig growth, but the intestinal mechanisms remain unclear. This study explored the impact of TRF on pig intestinal functions. Twelve male pigs were split into ad libitum feeding (FA) and TRF groups. FA pigs had free access to feed, whereas TRF pigs were fed during 07:00-08:00, 12:00-13:00, and 17:00-18:00. TRF enhanced crude protein digestibility by 18.9% (p = 0.045) and increased pancreatic chymotrypsin and lipase activities, while reducing ileal amylase, sucrase, and lipase activities. Transcriptomic analysis identified 1339 differentially expressed genes (DEGs) in the jejunum and 268 in the colon, indicating segment-specific responses. J

SUBMITTER: Wang H 

PROVIDER: S-EPMC12784904 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature