Secondary thalamic neuroinflammation associates with disturbed corticothalamic connectivity in a model of severe traumatic brain injury in male rats-a longitudinal study.

ABSTRACT: Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. The initial injury initiates a cascade of secondary injury mechanisms, including neuroinflammation and disruption of brain connectivity. In this study, we used the lateral fluid percussion injury model of TBI to investigate the relationship between secondary thalamic inflammation and corticothalamic connectivity disruptions. For this, we followed rats for six months post-injury, during which functional magnetic resonance imaging (fMRI) was conducted under light sedation, as well as diffusion tensor imaging (DTI) and positron emission tomography (PET). PET imaging with [18F]-FEPPA revealed neuroinflammation in the subacute stage in several ipsilateral thalamic nuclei, including the ventral posterior

SUBMITTER: Dvorakova L 

PROVIDER: S-EPMC12784941 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature