Potential of Higher Resolution Synchrotron Radiation Tomography Using Crystal Analyzer-Based Imaging Techniques for Differential Diagnosis of Human Lung Cancers.

ABSTRACT:

Background

Conventional absorption-based computed tomography has a limited ability to resolve lung microarchitectures that are critical for histological subtype discrimination. This study evaluated the potential of X-ray Dark-Field Imaging Computed Tomography (XDFI CT) using synchrotron radiation for non-destructive, three-dimensional visualization of human lung cancer microstructures.

Methods

Surgically resected human lung cancer specimens (n = 4) were examined, including acinar-predominant adenocarcinoma (n = 1), adenocarcinoma after concurrent chemoradiation therapy (n = 1), keratinizing squamous cell carcinoma (n = 1), and metastatic hepatocellular carcinoma in the lung (n = 1). Image acquisition was performed at beamline BL-14B of the

SUBMITTER: Yi E 

PROVIDER: S-EPMC12785047 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature