Outcomes of pPCL Diagnosed Using the IMWG 2021 Consensus Definition: A Retrospective Multicenter Analysis.

ABSTRACT:

Background

Primary plasma cell leukemia (pPCL) represents the most aggressive plasma cell dyscrasia with a poor prognosis and survival of <3 years. The International Myeloma Working Group (IMWG) adopted more inclusive diagnostic criteria for pPCL in 2021, including patients with 5% or more circulating plasma cells (down from 20%). Most published studies of pPCL do not include patients who meet the criteria for pPCL based on the newer diagnostic guidelines, and the data on the optimal treatment of pPCL is scarce. In our multi-center retrospective analysis, we report data on treatment regimens used in 67 pPCL patients to characterize outcomes in this population.

Methods

We included patients with newly diagnosed pPCL between 2010 and 2023 based on the 2021 IMWG definition at on

SUBMITTER: Venkatesh P 

PROVIDER: S-EPMC12785085 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature