Dietary Phytochemicals Targeting NRF2 Against Skin Cellular Senescence: Mechanistic Insights and Potential for Functional Food Development.

ABSTRACT: Skin aging is driven largely by oxidative stress, chronic inflammation, and mitochondrial dysfunction, processes closely linked to cellular senescence and declining NRF2 activity. Numerous dietary phytochemicals-such as curcumin (from turmeric), resveratrol (from grapes), sulforaphane (from cruciferous vegetables), zerumbone, and salvianolic acid B-abundant in fruits, vegetables, herbs, and traditional food sources, exhibit potent antioxidant and anti-inflammatory properties. This review systematically elucidates the molecular mechanisms by which these compounds mitigate skin aging, primarily through modulating the NRF2 signaling pathway. We further integrate insights from clinical trials of NRF2-targeting agents to inform the translational potential of these dietary bioactives. Molecular

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12785134 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature