Extracellular Vesicles From Chylomicron-Treated Endothelial Cells Drive Macrophage Inflammation.

ABSTRACT:

Background

Movement of circulating lipids into tissues and arteries requires transfer across the endothelial cell (EC) barrier. This process allows the heart to obtain fatty acids, its chief source of energy, and apoB-containing lipoproteins to cross the arterial endothelial barrier, leading to cholesterol accumulation in the subendothelial space. Multiple studies have established elevated postprandial TRLs (triglyceride-rich lipoproteins) as an independent risk factor for cardiovascular disease. We explored how chylomicrons affect ECs and transfer their fatty acids across the EC barrier.

Methods

We had reported that media from chylomicron-treated ECs lead to lipid droplet formation in macrophages. To determine the responsible component of this media, we assessed whether rem

SUBMITTER: Tilp A 

PROVIDER: S-EPMC12785161 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature