Gut virome dysbiosis contributes to premature ovarian insufficiency by modulating gut bacteriome.

ABSTRACT:

Background

Premature ovarian insufficiency (POI) significantly impairs female fertility and poses substantial health risks; however, its pathogenesis is incompletely understood, and effective therapeutic interventions are limited. Although gut bacteriome has been closely associated with ovarian dysfunction, the role and therapeutic potential of gut viruses, which far outnumber bacteria, remain largely unexplored.

Results

Therefore, we recruited 60 healthy reproductive-aged women and recently diagnosed POI patients and investigated these concerns using various techniques, including whole-genome shotgun sequencing of virus-like particle (VLP) and fecal virome transplantation (FVT) in CTX-induced POI rats. We found considerable interindividual variability in the gut virome. The

SUBMITTER: Jin J 

PROVIDER: S-EPMC12785201 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature