Sustained salivary IgG but short-lived IgA responses following primary and booster MenACWY-TT vaccination in older adults.

ABSTRACT: Carriage of Neisseria meningitidis is essential in meningococcal transmission and is a prerequisite for invasive meningococcal disease (IMD). Meningococcal conjugate vaccines have been suggested to reduce acquisition of carriage in adolescents and young adults, contributing to herd protection. Mucosal immunity is considered key in protection against colonization. While mucosal antibody responses following parenteral meningococcal conjugate vaccination have been described in infants, adolescents and young adults, data in older adults, who are at increased risk for infectious diseases including IMD, are limited. This phase IV, open-label clinical trial (CTIS: 2024-513640-29-00) assessed antibody responses in saliva in 216 adults aged 65-85 y following primary meningococcal serogroup A

SUBMITTER: Visser M 

PROVIDER: S-EPMC12785227 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature