The Transcription Factor PoCon7 Is Essential for Fungal Viability and Regulates Chitinase Gene Expression in <i>Penicillium oxalicum</i>.

ABSTRACT: The dynamic remodeling of the fungal cell wall depends on a balance between chitin synthesis and degradation. Chitinases are critical for nutrient acquisition, cell wall remodeling, and defense; yet, the upstream regulatory mechanisms controlling chitinase gene expression remain poorly understood. Here, Tandem Affinity Purification-Mass Spectrometry (TAP-MS) with the Penicillium oxalicum Snf1 kinase (PoSnf1) as bait identified the zinc finger transcription factor (TF) PoCon7 as a putative target of the Snf1 kinase complex. This complex comprises the catalytic α subunit Snf1, one of three alternative β subunits Gal83, and the γ subunit Snf4. Although PoCon7 does not directly bind PoSnf1 or PoSnf4, it specifically interacts with PoGal83. Phylo

SUBMITTER: Ma K 

PROVIDER: S-EPMC12785316 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature