Dissecting the Biological Functions of Various Isoforms of Ferredoxin Reductase for Cell Survival and DNA Damage Response.

ABSTRACT: The ferredoxin reductase (FDXR) gene is expressed as seven isoforms: 1-6 by alternative splicing and 7 by an alternative promoter according to the Entrez Gene Database. Previous studies showed that FDXR, primarily the mitochondrial isoform 1, plays a role in biosynthesis of sterols, heme, and iron-sulfur clusters. However, the biological functions of FDXR isoforms 3-7 have not been characterized. Here, we first examined the expression profile of various FDXR isoforms. We found that isoform 1 is the most abundant one, accounting for ~70% of total FDXR, whereas isoforms 4 and 7 account for ~10% and ~7%, respectively. We found that isoforms 1 and 4 are mainly localized in the mitochondria, whereas isoform 7, which lacks a mitochondria localization signal (MLS), is expressed in the cyto

SUBMITTER: Nakajima KI 

PROVIDER: S-EPMC12785329 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature