Polysaccharide from <i>Artocarpus heterophyllus</i> Lam. Pulp Ameliorates Cyclophosphamide-Induced Intestinal Damage by Regulating Gut Microbiota and Co-Metabolites.

ABSTRACT:

Background

Polysaccharides modulate host health by interacting with gut microbiota and reshaping the host-microbial metabolome, potentially facilitating immune regulation.

Methods

This study evaluated the modulatory effect of Artocarpus heterophyllus Lam. (jackfruit) polysaccharide (JFP-Ps) against cyclophosphamide (Cy)-induced immunosuppression in mice, focusing on gut microbiota modulation and metabolite changes.

Results

JFP-Ps effectively increased the beneficial bacteria ratio, such as Lactobacillus and Lachnospiraceae, while inhibiting some species like Akkermansia. Metabolomic analysis showed that JFP-Ps notably regulated gut microbe-associated metabolites, including short-chain fatty acids (SCFAs), amino acids, bile acids, indoles, a

SUBMITTER: He Z 

PROVIDER: S-EPMC12785341 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature