Multi-Omics Mechanism of Chronic Gout Arthritis and Discovery of the Thyroid Hormone-AMPK-Taurine Metabolic Axis.

ABSTRACT: The acute gouty arthritis (AGA) to chronic gouty arthritis (CGA) transition is a critical phase leading to irreversible joint damage and systemic complications. However, current molecular mechanism investigations have remained limited to single-omics approaches that lack comprehensive multi-omics explorations. We integrate high-depth data-independent acquisition (DIA) proteomics and untargeted metabolomics to analyze serum samples from healthy controls (n =28), AGA (n = 31), and CGA (n = 14) patients to address this gap. Through differential expression analysis, we identified nine persistently dysregulated pivotal proteins with robust discriminative capacity, including the urate excretion regulator ZBTB20 and inflammation/immune-related proteins (GUCY1A2, CNDP1, LYZ, S

SUBMITTER: Zhu G 

PROVIDER: S-EPMC12785424 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature