Elevated SASP Factors, Reduced Antioxidant Enzymes, and Increased Tumor Susceptibility in Space Radiation-Exposed <i>Apc</i>^Min/+ Mice.

ABSTRACT: Human missions into deep space will expose astronauts to the unique and complex radiation environment of galactic cosmic radiation (GCR), a mixed field of high-energy protons and heavy ions predicted to substantially increase long-term cancer risk. To support effective risk stratification, early detection, and mitigation strategies, there is a need to identify biomarkers indicative of GCR-induced cancer risk. Here, we applied a Tandem Mass Tag (TMT)-based quantitative proteomics approach to identify potential biomarkers associated with GCR-induced gastrointestinal (GI) and mammary tumorigenesis using the female Apc^Min/+ mouse, a well-established model of human colorectal and breast cancer. Eight- to ten-week-old Apc^Min/+ mice were exposed to 75 cGy of si

SUBMITTER: Kumar K 

PROVIDER: S-EPMC12785459 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature