Glucosinolate-Myrosinase Formulations for Adult Obesity: Towards Next Generation of Bioactive Therapies.

ABSTRACT: The rising global prevalence of obesity and metabolic disorders calls for innovative dietary strategies that can modulate key enzymatic pathways involved in lipid and carbohydrate metabolism. This study uncovers the effects of sulforaphane (SFN)-rich broccoli-derived formulations-including liquid and lyophilised forms, as well as two commercial prototypes, Sulforaphan^® BASIC and Sulforaphan^® SMART, the latter being characterised by the inclusion of an enteric-coated myrosinase enzyme designed to enhance the in situ conversion of glucosinolates (GSL) into bioactive isothiocyanates (ITC)-on lipid and carbohydrate metabolism in 3T3-L1 adipocytes. Across the formulations, total GSL content ranged widely, with GS0 showing the highest levels. Functionally, all SFN-rich form

SUBMITTER: Medrano-Padial C 

PROVIDER: S-EPMC12785495 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature