Avenanthramide C From Oats Possibly Exerts Anti-Inflammatory Effects in Human Umbilical Vein Endothelial Cells.

ABSTRACT: Chronic kidney disease (CKD) is associated with inflammation and cardiovascular complications and is partly exacerbated by the uremic toxin indoxyl sulfate (IS). IS is known to activate the aryl hydrocarbon receptor (AhR) to promote vascular inflammation. On the other hand, avenanthramide C (Ave), an oat-derived polyphenol, has antioxidative and anti-inflammatory properties. Therefore, we investigated whether Ave can suppress IS-induced inflammatory responses. Analysis of serum from hemodialysis patients revealed a significant correlation between IS and interleukin-6 (IL-6) levels. In human umbilical vein endothelial cells (HUVECs), IS (≥50 µg/mL) increased IL-6 secretion, while Ave (≥10 µM) suppressed this effect. Docking simulations and in vitro experiments suggested that Ave may interac

SUBMITTER: Sasaki H 

PROVIDER: S-EPMC12785505 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature