An Integrated Multi-Omics Study of Mammalian Skeletal, Cardiac, and Smooth Muscles.

ABSTRACT: Muscle tissue, as a major tissue type, is classified by its structure and function into smooth, cardiac, and skeletal muscle. However, comprehensive studies on the evolutionary conservation of molecular differences among these three muscle tissues have been limited. In this study, we employed pigs and mice as models to perform multi-omics profiling (transcriptome, proteome, and metabolome) of these three muscle tissues in order to define their molecular landscapes. Furthermore, we characterized skeletal muscle metabolic heterogeneity. We identified 207 genes enriched in striated muscle, including poorly characterized genes such as LRRC2 and PPP1R14C. Distinct sets of genes and metabolites, conserved between the two species, were specifically enriched in each tissue: skeletal

SUBMITTER: Tang S 

PROVIDER: S-EPMC12785520 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature