Transcriptome Dynamics and Regulatory Networks of Postnatal Muscle Development in Leizhou Black Goats.

ABSTRACT: Postnatal muscle development involves complex transcriptional regulation that remains poorly characterized in goats. This study employed RNA-Seq to profile the Longissimus dorsitranscriptome of Leizhou Black goats across three developmental stages: birth, six months, and two years. We identified dynamic gene expression patterns, widespread alternative splicing events, and stage-specific co-expression networks that collectively orchestrate muscle maturation. A significant transcriptional shift occurred between six months and two years, marked by the downregulation of proliferation-related genes (e.g., RRM2, TOP2A) and the activation of pathways governing muscle contraction and energy metabolism. Functional enrichment analyses highlighted the importance of PI3K-Akt, PPAR, and c

SUBMITTER: Han J 

PROVIDER: S-EPMC12785553 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature