Polyethylene Glycol (PEG)-Based Wet-Adhesive Absorbable Bone Wax for Osseous Hemostasis and Repair.

ABSTRACT: The non-absorbability and biological inertia of traditional bone wax often result in foreign body retention, inhibit bone healing, and increase the risk of infection. Herein, a novel absorbable bone wax was developed by mixing polyethylene glycol (PEG), tannic acid (TA), sodium carboxymethyl cellulose (CMC), and low-molecular-weight poly-L-lactic acid (PLLA) via one-pot method. Among them, PEG functions as the matrix, endowing it with plasticity and hydrophilicity, thereby facilitating its facile, close fit to the surface of bone defects. TA, with its profusion of phenolic hydroxyl groups, bestows the material with exceptional adhesion properties. The hydroxyl and carboxyl groups in the CMC molecular structure are capable of forming hydrogen bond networks with PEG and TA. Concurrently, hyd

SUBMITTER: Cheng H 

PROVIDER: S-EPMC12785556 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature