Structure-Function Interplay in Piezoelectric PCL/BaTiO₃ Scaffolds Fabricated by Phase Separation: Correlation of Morphology, Mechanics, and Cytocompatibility.

ABSTRACT: Bone regeneration relies on the coordinated interplay between mechanical and biological cues. Piezoelectric composites, capable of converting mechanical strain into electrical signals, offer a promising approach to stimulate osteogenesis. This study aimed to develop and characterize polycaprolactone (PCL) and barium titanate (BaTiO₃) composite scaffolds fabricated through thermally induced phase separation (TIPS), and to systematically evaluate the effects of polymer concentration and ceramic incorporation on scaffold morphology, porosity, mechanical properties, and cytocompatibility were systematically evaluated. The resulting scaffolds exhibited a highly porous, interconnected architecture, with 9% PCL formulation showing the most uniform morphology and consistent mechanical a

SUBMITTER: Alotaibi A 

PROVIDER: S-EPMC12785586 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature