Plasma Levels of Food-Derived Metabolites as Biomarkers of Parkinson's Disease.

ABSTRACT: Parkinson's disease (PD) is a progressive neurodegenerative disorder shaped by genetic factors such as LRRK2 and GBA1 mutations, as well as dietary and metabolic influences. Food-derived plasma metabolites-including caffeine, paraxanthine, trigonelline, piperine, and sitosteryl hexoside-have emerged as promising, accessible biomarkers for early detection, progression monitoring, and therapeutic targeting, yet their longitudinal behavior and genetic interactions remain insufficiently characterized. Using the Parkinson's Progression Markers Initiative (PPMI) cohort (n = 455; 303 PD patients, 152 controls), we quantified plasma levels of these metabolites by quantitative LC-MS/MS with batch correction, examining sporadic PD and genetically defined subgroups (LRRK2-

SUBMITTER: Dong X 

PROVIDER: S-EPMC12785599 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature