The Myeloid Biomarker <i>MS4A6A</i> Drives an Immunosuppressive Microenvironment in Glioblastoma via Activation of the PGE2 Signaling Axis.

ABSTRACT: Glioblastoma (GBM) remains one of the most lethal brain tumors, characterized by extensive immune evasion and a macrophage-dominated tumor microenvironment (TME). However, the molecular determinants governing tumor-associated macrophage (TAM) states and their immunoregulatory functions remain poorly understood. We integrated bulk- and single-cell transcriptomic datasets (TCGA, CGGA, Ivy GAP, and Brain Immune Atlas) to systematically characterize the expression, prognostic relevance, and immune contexture of the myeloid biomarker membrane-spanning 4-domain A6A, MS4A6A, in GBM. Differential expression, survival, and pathway enrichment analyses were performed. Single-cell mapping and CellChat modeling delineated MS4A6A-associated TAM subpopulations, intercellular communication n

SUBMITTER: Chen J 

PROVIDER: S-EPMC12785608 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature