Optimization of the Contrast Concentration for Low-Tube-Voltage Chest CT: A Randomized Controlled Trial with Low-Concentration Contrast Media.

ABSTRACT: Objective: To evaluate the effect of low-concentration contrast media (LCCMs) on 100 kVp conventional chest CT by comparing the proportions of acceptable-quality scans obtained using various CM concentrations with those obtained using the standard protocol. Materials and Methods: This prospective, multicenter, randomized controlled trial enrolled adult patients with BMI < 30 who underwent enhanced chest CT between December 2023 and September 2024. Participants were randomly assigned to four groups: one control group (120 kVp, 320 mgI/mL) and three test groups using 100 kVp and standard CM (320 mgI/mL) or LCCMs (270 or 240 mgI/mL). Non-inferiority was tested based on the proportion of acceptable-quality scans independently assessed by two readers. Adverse reactions, including

SUBMITTER: Park J 

PROVIDER: S-EPMC12785640 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature