CaMKII Neurons in the Dentate Gyrus Are Involved in Regulating Cognitive Impairment in Mice Induced by Stress Caused by Violence.

ABSTRACT: Post-stress cognitive impairment (PSCI) is defined as a persistent neuropsychiatric condition characterized by deficits in memory consolidation, executive functioning, and environmental interaction following exposure to violent stress. Despite its high incidence, PSCI remains underdiagnosed and lacks effective therapeutic strategies, posing a substantial societal burden and highlighting a critical gap in neuropsychiatric research. A major constraint in mechanistic studies is the persistent reliance on conventional paradigms, notably the Y-maze and novel object recognition test. Their limited sensitivity and poor translational relevance to human cognitive dysfunction, compounded by slow methodological innovation, significantly impede progress. Furthermore, the specific brain regions or neur

SUBMITTER: Shao G 

PROVIDER: S-EPMC12785653 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature