Polysaccharides from Citrus Fruit with Different Mastication Traits Ameliorate DSS-Induced Ulcerative Colitis by Restoring Intestinal Barrier Function and Microbiota Balance.

ABSTRACT: Mastication trait is an important indicator for evaluating citrus fruit texture and may modulate the biological activity of citrus polysaccharides. This study compared the protective effects of pulp polysaccharides from citrus fruit with different mastication traits, namely Hongmeiren (HMR, superior), Satsuma (WM, moderate), and Nanfeng tangerine (NF, inferior mastication trait) on ulcerative colitis (UC) in mice. All polysaccharides alleviated UC symptoms, with HMR showing the most pronounced effects by more markedly reducing TNF-α levels, while enhancing IL-10, ZO-1, Occludin, and MUC2 expression. NF exhibited a stronger inhibitory effect on IL-6. Microbiota analysis revealed that citrus polysaccharides suppressed Escherichia-Shigella and Helicobacter, enriched Akkermansia and

SUBMITTER: Yao J 

PROVIDER: S-EPMC12785777 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature