Shape and Morphology of the Sella Turcica in Patients with Trisomy 21-A Systematic Review.

ABSTRACT: Background/Objectives: The sella turcica (ST) is a central craniofacial and endocrinological landmark whose morphology reflects both local skeletal development and systemic influences. Alterations in its form have been observed in various genetic syndromes, including trisomy 21 (Down syndrome, DS). Considering the characteristic craniofacial morphology of DS, this review aimed to evaluate whether individuals with DS present distinctive morphometric features and shape variants of the ST compared with non-syndromic populations and to discuss their diagnostic and clinical relevance. Methods: A systematic literature search was carried out in PubMed, the Cochrane Library, Web of Science, Wiley, MDPI, and Google Scholar on 8 May 2024. Search terms included "sella turcica," "Down sy

SUBMITTER: Mazus M 

PROVIDER: S-EPMC12785798 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature