Assessment of the Diagnostic Value of [⁶⁸Ga]Ga-FAPI-04 and [¹⁸F]FDG PET in a PHMG-p-Induced Pulmonary Fibrosis Murine Model.

ABSTRACT: Background/Objectives: Pulmonary fibrosis is a progressive and fatal lung disease with limited diagnostic and therapeutic options. Fibroblast activation protein (FAP) has emerged as a promising molecular imaging target for the non-invasive assessment of fibrotic activity. This study aimed to evaluate the diagnostic feasibility of [⁶⁸Ga]Ga-FAP inhibitor (FAPI) and [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) positron emission tomography (PET) for imaging pulmonary fibrosis in a mouse model. Methods: A pulmonary fibrosis model was established by intratracheal administration of polyhexamethylene guanidine-phosphate (PHMG-p) to C57BL/6 mice. Fibrosis severity was quantified by the Ashcroft scoring system using hematoxylin and eosin and Masson's trichrome st

SUBMITTER: Kim SY 

PROVIDER: S-EPMC12785816 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature