Supernatants from Water Extraction-Ethanol Precipitation of <i>Fagopyrum tararicum</i> Seeds Enhance T2DM Management in Mice by Regulating Intestinal Microbial Communities.

ABSTRACT: Type 2 diabetes mellitus (T2DM) is an endocrine-metabolic disorder characterized by pancreatic islet dysfunction-induced hyperglycemia, which triggers hepatic injury, intestinal microbiota dysbiosis, and systemic complications. Fagopyrum tararicum seeds exhibit various biological activities, including antioxidant, hypolipidemic, and antihypertensive effects. However, there is limited research exploring how supernatants derived from the water extraction-ethanol precipitation of Fagopyrum tararicum seeds (SWEPFT) modulate the intestinal microbiota and their potential link to T2DM. This study evaluates SWEPFT's effects on hyperglycemia and intestinal microbiota in T2DM mice. After a 4-week therapeutic period, SWEPFT markedly ameliorated hyperglycemia, as evidenced by redu

SUBMITTER: Ge X 

PROVIDER: S-EPMC12785855 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature