Cellular Immunological Memory T Cells and <i>IL15RA</i> Gene Polymorphism in COVID-19 Vaccinated Individuals from Southern Brazil.

ABSTRACT: Background: The development of safe and effective vaccines against SARS-CoV-2 was crucial for controlling COVID-19 and establishing long-lasting immune memory in the population. Methods: This study evaluated cellular immune memory in individuals vaccinated with different regimens in Rio Grande do Sul using flow cytometry. Additionally, the rs2228059 polymorphism in the IL15RA gene was genotyped. A total of 62 participants were randomly recruited. Results: A decrease in memory T cell subsets in response to SARS-CoV-2 stimuli was observed in total CD3⁺, CD4⁺, and CD8⁺ T cells. Regarding the timing of the last vaccine dose, 94.4% of participants had received their final COVID-19 vaccination at least two years prior to recruitment. T

SUBMITTER: Rodrigues GM 

PROVIDER: S-EPMC12785960 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature