The Role of Metabolites in Cell-Cell Communication: A Review of Databases and Computational Tools.

ABSTRACT: Cell-cell communication (CCC) is essential for multicellular organisms, enabling different cell types to coordinate their activities in both physiological and pathological contexts, such as cell growth, proliferation, tumorigenesis, and immune responses. Metabolites represent an important class of signaling molecules, though their signaling roles were long underappreciated. Growing evidence has highlighted the critical involvement of metabolites in CCC, and the advent of single-cell RNA sequencing (scRNA-seq) has enabled high-resolution exploration of CCC events. This review summarizes existing metabolite-sensor databases and computational tools developed to identify metabolite-mediated CCC using scRNA-seq data. Nonetheless, these databases exhibit considerable variability due to lack of u

SUBMITTER: Song Q 

PROVIDER: S-EPMC12786037 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature