Integrative Bioinformatic and Epidemiological Analysis of Acetaminophen Use and Risk of Sex Hormone-Related Cancers.

ABSTRACT: Acetaminophen (paracetamol) is one of the most widely used analgesic and antipyretic drugs worldwide, yet its potential impact on hormonal balance and the risk of hormone-dependent cancers remains unclear. This study aimed to integrate epidemiological and bioinformatic evidence to assess the association between acetaminophen use and the risk of sex hormone-related cancers. A systematic review of preclinical and human studies was complemented by in silico analyses of acetaminophen's molecular targets and their involvement in cancer-related pathways. Epidemiological data indicate that, although experimental studies suggest possible hormonal and reproductive effects, most population-based studies do not support an increased cancer risk, and some even suggest a potential protective effect. Bio

SUBMITTER: Gorawski F 

PROVIDER: S-EPMC12786045 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature