Flavin Biosynthesis Enhances Extracellular Electron Transfer in Bioengineered Escherichia coli.

ABSTRACT: Advancements in bioengineering have unlocked new microbial electrochemical applications in energy, sensing, remediation, and synthesis. Key to realizing these technologies is the engineering of conduits in metabolically versatile microbes like Escherichia coli to enable efficient charge exchange with the electrode. Inspired by mechanisms found in natural exogelectrogens, previous studies have largely focused on introducing conduits based on the metal-reducing (Mtr) pathway in Shewanella oneidensis MR-1. This study explores the concomitant expression of flavin secretion pathways for mediated charge transfer to complement the direct charge transfer from the bioengineered Mtr pathway. The engineered strains show a 3-fold increase in the total secretion of flavin mononucleotide (FMN) and ribof

SUBMITTER: Mouhib M 

PROVIDER: S-EPMC12786374 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature