Discovering the Anti-Inflammatory Potential of Compounds Isolated from the Aerial Parts of <i>Gelasia tomentosa</i> (L.) Zaika, Sukhor. & N.Kilian (Syn. <i>Scorzonera tomentosa</i>), Through In Vitro Techniques and Advanced In Silico Modeling Approaches.

ABSTRACT: Gelasia tomentosa (L.) Zaika, Sukhor. & N.Kilian which is known formerly as Scorzonera tomentosa L., a wild edible plant species in Turkey, is traditionally used against rheumatism and for wound healing. In this study, we explore its anti-inflammatory compounds, evaluating effectiveness through human red blood cell stabilization and in silico models, alongside physico-chemical and pharmacokinetic profiles. In vitro activity-guided fractionation allowed the isolation of sixteen compounds from the aerial parts of G. tomentosa, which were identified as hyperoside (1), isoquercetin (2), quercetin 3-O-β-apiofuranosyl-(1→2)-β-galactopyranoside (3), quercetin 3-O-β-apiofuranosyl-(1→2)-β-glucopyranoside (4),

SUBMITTER: Bahadır-Acıkara O 

PROVIDER: S-EPMC12786445 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature