Atypical Femur Fractures Without Bisphosphonate Exposure (AFFwB): A Retrospective Report of 21 Cases.

ABSTRACT: Background/Objectives: Atypical femoral fractures (AFFs) are rare and classically linked to long-term bisphosphonate therapy, but many occur without such exposure. We aimed to characterize atypical femoral fractures without bisphosphonate exposure (AFFwB) in older adults and to explore biochemical patterns using principal component analysis (PCA). Methods: We conducted a retrospective study of patients ≥65 years admitted with femoral fractures (January 2019-September 2024). AFFs were identified from ICD-9 codes and confirmed according to 2014 ASBMR criteria by two blinded reviewers. Demographic, clinical, densitometric, and metabolic data were collected. Correlations between biochemical variables were assessed, and PCA was applied to PTH, vitamin D, BMD, ALP, calcium, and cre

SUBMITTER: Lucchetta L 

PROVIDER: S-EPMC12786818 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature