Prognostic Value of Serum S100B Protein for Neurological Outcomes After Cardiac Arrest: A Systematic Review and Meta-Analysis.

ABSTRACT: Background/Objectives: Cardiac arrest (CA) continues to be one of the leading causes of mortality and long-term neurological disability worldwide. Accurate early neuroprognostication after return of spontaneous circulation is essential for guiding post-resuscitation care. The calcium-binding astrocytic protein S100B has been identified as a potential biomarker for hypoxic-ischemic brain injury. This systematic review and meta-analysis assessed the prognostic and diagnostic efficacy of serum S100B in forecasting neurological outcomes after CA. Methods: Thorough searches of PubMed, Embase, Scopus, Web of Science, CENTRAL, and CINAHL from their inception to November 2025 uncovered 40 observational studies. Results: Pooled analyses employing random-effects models revealed

SUBMITTER: Szpinda L 

PROVIDER: S-EPMC12786873 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature