Modulation of Behavioral, Biochemical, Immunomodulatory, and Transcriptional Profiles by the Strain <i>Limosilactobacillus fermentum</i> U-21 in Combined Model of Parkinson's Disease in Wistar Rats.

ABSTRACT: Since there is currently no cure for Parkinson's disease, pharmacobiotic approaches based on gut microbiota-capable of producing pharmacologically active compounds-are under development. In this study, we propose LfU21, derived from the strain Limosilactobacillus fermentum U-21, as a candidate pharmacobiotic. To evaluate its efficacy, a combined LPS- and lactacystin (LAC)-induced Parkinson's disease model was established in Wistar rats. Effects were assessed using behavioral, biochemical, immunomodulatory, and transcriptomic biomarkers. LfU21 administration reduced α-synuclein levels, altered motor performance in the "Rung ladder" test, and modulated bdnf gene expression in the right and left striata. Under LPS exposure, LfU21 prevented alterations in immune response markers,

SUBMITTER: Reznikova DA 

PROVIDER: S-EPMC12786881 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature