Identification of Differentially Expressed Genes and SNPs Linked to <i>Vibrio mimicus</i> Resistance in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>).

ABSTRACT: Vibrio mimicus infection poses a severe threat to the sustainable aquaculture of yellow catfish (Pelteobagrus fulvidraco), a commercially important freshwater species of the order Siluriformes. To reveal the genetic mechanisms underlying the resistance to this pathogen, we established an infection model and integrated genome-wide association study (GWAS) and transcriptomics to identify key resistance loci and genes. Firstly, from whole-genome re-sequencing (WGRS) and high-quality genotypic data, six SNP loci significantly associated with resistance to V. mimicus were identified, which were annotated to 17 immune-related candidate genes. Notably, the rac2 gene associated with the locus Chr15:3,227,652 exhibited significantly differential expression in skin tissue

SUBMITTER: Tong W 

PROVIDER: S-EPMC12786896 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature