Hyaluronidase Use in Aesthetic Medicine: Formulations, Safety, and Clinical Practice.

ABSTRACT: The rising number of Hyaluronic acid (HA) filler applications has led to an increase in the incidence of complications, which can range from undesired aesthetic outcomes to severe vascular occlusion events. Hyaluronidase (Hyal) hydrolyzes HA molecules and represents the preferred treatment for managing complications associated with HA fillers. Although Hyal formulations are safe and effective, Hyal use for treating complications of aesthetic procedures remains off-label in many countries due to the lack of standardized protocols and varying recommendations on dosing strategies. Here, we review the use of Hyal in aesthetic medicine, focusing on the available formulations, including galenic preparations, and the associated risks. We provide an update on the current clinical practice for Hyal

SUBMITTER: Arrigoni F 

PROVIDER: S-EPMC12787120 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature