Anthonoic Acids A-C, Sulfated and <i>N</i>-(2-Hydroxyethyl)-Substituted Lipidic Amino Acids from the Marine Sponge <i>Antho ridgwayi</i> with In Vitro Cytoprotective Activities.

ABSTRACT: Anthonoic acids A-C (1-3), the first representatives of sulfated and N-(2-hydroxyethyl)-substituted lipidic α-amino acids, were isolated along with their plausible precursor, anthamino acid A (4), from the marine sponge Antho ridgwayi. The structures of these compounds were determined using the analysis of 1D and 2D NMR and HR ESI mass spectra. A structural feature of 1-4, compared to all previously known lipidic amino acids, is the presence of a sulfate group near the end opposite the amino acid terminus. At a concentration of 1 µM, anthonoic acids A-C (1-3) effectively protected H9c2 and SH-SY5Y cells in biotests, which modeled hypoxia induced by the addition of CoCl₂ to the medium and damage caused by ische

SUBMITTER: Guzii AG 

PROVIDER: S-EPMC12787137 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature