Real-World Safety of Cyproheptadine-Based Appetite Stimulants: An Electronic Health Record-Based Retrospective Cohort Study in Adult Patients.

ABSTRACT: Background: Cyproheptadine-based appetite stimulants (CAS) have been safely used in Korea for over 30 years. However, in older adults who are vulnerable to malnutrition, sarcopenia, and fall-related morbidity, safety of CAS in nutrition care remains uncertain due to limited evidence and its antihistaminic effects. This study aimed to assess the real-world safety of CAS compared with megestrol and other antihistamines to inform safe pharmacologic support within clinical nutrition practice. Methods: A retrospective observational study was conducted using Seoul National University Hospital's common data model. Patients who were prescribed CAS, megestrol, or antihistamines between 2004 and 2022 were enrolled. To balance covariates, propensity score matching was applied. The prima

SUBMITTER: Ko M 

PROVIDER: S-EPMC12787220 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature