Novel Acrylic Bone Cement Containing Graphene Oxide: Synthesis and Characterization.

ABSTRACT: Polymethylmethacrylate (PMMA) bone cement is widely used in orthopedics, accounting for approximately 80% of knee joint replacements in the United States. While prosthesis designs and materials have evolved to improve performance and durability, PMMA cement has undergone minimal compositional changes. Carbon-based nanomaterials, particularly graphene oxide (GO), have attracted interest for their ability to enhance the mechanical and thermal properties of orthopedic cements. This study evaluated the effects of incorporating different GO concentrations into PMMA bone cement on its mechanical properties, cytocompatibility, and antibacterial activity. PMMA was modified with GO at 0.1, 0.25, and 0.5 weight percent (wt%) for mechanical and antibacterial tests, and at 1.0 wt% for cytocompatibilit

SUBMITTER: Gularte LFG 

PROVIDER: S-EPMC12787345 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature