Regulation of Plasmodesmata Function Through Lipid-Mediated PDLP7 or PDLP5 Strategies in <i>Arabidopsis</i> Leaf Cells.

ABSTRACT: Plasmodesmata (PDs) are enriched in sphingolipids and sterols, creating a specialized environment for regulatory proteins like plasmodesmata-localized proteins (PDLPs). How PDLPs regulate PD function in a specific lipid environment remains poorly understood. Here, we provide a unique insight from the interaction network of two different PDLPs together with sphingolipids and propose a concept that PDLPs form homo- or hetero-dimers only in the presence of sphingolipids. Located in the detergent resistance region, PDLP7 demonstrated the ability to influence the sphingolipid composition in PD-enriched fraction, particularly the GIPC content, and finally, modulating the membrane order. The presence of sphingolipids, in turn, affected the oligomeric state of PDLP7 in membranes. The PDLP7 recombi

SUBMITTER: Chen X 

PROVIDER: S-EPMC12787549 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature