Developmental regulation of Erk signaling by mitotic kinases.

ABSTRACT: During the peri-implantation phase of murine embryogenesis, the epiblast proliferates rapidly and undergoes epithelialization. At the same time, the preimplantation pluripotent state transforms into a more developmentally advanced, pregastrulation state. While extensive research has elucidated cell-extrinsic signals that direct the developmental progression, such as the Fgf/Mek/Erk pathway, the potential interplay of intrinsic cellular cues remains largely unexplored. To address this, we conducted a comprehensive phenotypic screen using an in vitro model of epiblast development. We identified aurora kinase A as a cell-intrinsic factor contributing to Erk activation and transcriptional response. Consequently, suppressing aurora kinase A activity delayed exit from naïve pluripotency. Moreove

SUBMITTER: Chen F 

PROVIDER: S-EPMC12787582 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature