Cocrystals of 1,2-Diiodotetrafluorobenzene with Pyridine Derivatives: Pyridine Nitrogen as a Bifurcated Acceptor with Ortho-Diiodo Halogen Bond Donors.

ABSTRACT: The behavior of 1,2-diiodotetrafluorobenzene (12tfib) as a halogen bond donor was studied by cocrystallizing it with a series of aromatic nitrogen bases covering a wide range of pK _a values (2.10 ≤ pK _a ≤ 9.60) and comparing the results with those reported for other perfluorinated iodobenzenes. The cocrystal screening was performed by grinding 12tfib and each of the selected bases in a 1:2 donor:acceptor stoichiometric ratio as well as crystallization from solution in a small excess of the acceptor (ratio 1:2.5). Of the 14 bases used in this study, three weakest bases (pK _a below ca. 4) have failed to produce cocrystals, nine intermediate bases (4.85 ≤ pK _a ≤ 6.72) have yielded four new phases, which were

SUBMITTER: Bedekovic N 

PROVIDER: S-EPMC12787666 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature