Zn-IMP 3D Coordination Polymers for Drug Delivery: Crystal Structure and Computational Studies.

ABSTRACT: Coordination polymers (CPs) are garnering attention in the field of medicine day by day. The goal is to develop a CP with biosafe and environment-friendly characteristics. Herein, we report two such novel 3D coordination polymers of zinc-inosine-5'-monophosphate (Zn-IMP) and bpe/azpy (as linkers) which were engineered as metal-organic frameworks that can be used as drug carriers for hydroxyurea (HU). We employed SCXRD, PXRD, solid-state CD, FTIR and TGA for crystal structure characterizations; the results achieved 3D coordination polymers which contain a P2₁ space group with chiral distorted tetrahedral geometry. Solution phase studies like UV-vis and CD were carried out to understand mechanistic pathways for interaction and chirality, respectively. We have also performed

SUBMITTER: Aqil HZ 

PROVIDER: S-EPMC12787693 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature